coffee and neurological disease (neurological diseases)
are generally considered public salty drank 200 milligrams of caffeine (about 2.5 cups of coffee), or a day to drink no more than 400 milligrams of caffeine (5 cup), there would be no harm to the body, the brain and the nervous system health and alertness, focus has helped, and can reduce the risk of depression, as well as strengthening the role of the drug headache and so on. Long-term use of coffee or caffeine to prevent cognitive decline, and may reduce the risk of stroke, Parkinson’s disease and Azihaimo disease, but may increase some people’s anxiety and disrupt sleep. In epilepsy, the role of coffee still controversial, studies in animal models and found that short-term caffeine will reduce seizure threshold, making it easier attack, but on the contrary, in the human study found that long-term use of coffee / caffeine, can reduce brain damage and reduce seizures status epilepticus (status epilepticus) when. Coffee beans alcohol (kahweol) can protect nerve cells from damage, for example to protect the cause of Parkinson’s disease neurotoxin 6-hydroxydopamine (6-hydroxydopamine; 6-OHDA ) neuronal cells from death.Study found that alcohol can beans via phosphatidylinositol 3-kinase (phosphatidylinositol 3-kinase; PI3K) pathway and p38 / Nrf2, induction of heme oxygenase original -1 (heme oxygenase-1), via the 6-hydroxy derivative oxidative stress (6-hydroxydopamine-derived oxidative stress ), in order to protect dopamine neurons. Coffee machine by multiplex switch reduces the relative risk of Parkinson’s disease,Parkinson’s disease (Parkinson’s disease) is the incidence of disease after Azihaimo neurodegenerative diseases, the cause remains unknown, but because of brain substantia nigra brain cell degeneration, can not produce enough dopamine (dopamine) related. Why substantia nigra cells degenerate it?It is unclear, presumably, may be related to genetic, environmental or lifestyle factors, such as misuse of antibiotics, heavy metals pollution. Several recent studies have shown that coffee can actually prevent Parkinson’s disease. 60~80% of Parkinson’s disease patients have constipation problems, but early in the onset of symptoms is 10 to 20 years ago began. In 2014, the team at National Taiwan University Hospital of the Ministry of Health Insurance Analysis library 550 000 cases of Parkinson’s disease, has once again confirmed that people who have constipation troubled future chances to get Parkinson’s disease higher than the average of many people, and the more severe constipation , the higher the probability. ((To reduce the risk of dementia drink several cups of coffee good? The answer is on the next page))
Constipation may be related to intestinal bacteria, intestinal bacteria in patients with Parkinson’s does have considerable differences with healthy people.
Derkinderen, who studied the relationship between cigarettes, coffee, intestinal bacteria and Parkinson’s disease, believed that when intestinal bacteria for various reasons tend to gradually phase when inflammation-type intestinal bacteria, intestinal immune cells and glial cells (EGC) secrete large amounts of inflammatory cytokines, induce intestinal nerve cells (EN) formed within harm nerve cells (denatured protein aggregate Lewy body; LB), this pathological phenomenon will slowly progress through the vagus nerve to the brain locus coeruleus (LC) and substantia nigra (SN) sites, a few years later induce Parkinson’s disease. Coffee may prevent Parkinson’s disease because they cause inflammation of the intestinal microflora type gradually changed into an anti-inflammatory type of intestinal microflora. At present, there are laboratory developed a spirit of probiotics (psycho-biotics) PS128, is a super anti-inflammatory probiotics, is expected to help maintain a healthy intestinal bacteria type of anti-inflammatory intestinal microflora of healthy mice , depression rats or mice fed sterile PS128, can significantly enhance the concentration of dopamine in the brain.Currently, there are technical studies using genome-wide basis (genome wide-based) proposed coffee reduces the risk of Parkinson’s disease may be associated with glutamate receptor gene (glutamate receptor gene) GRIN2A related argument, but to accept hormone replacement therapy (HRT) in postmenopausal women had no protective effect. Hu et Finnish study found that drinking a cup of coffee a day ~ 4 people, future opportunities for the occurrence of Parkinson’s disease reduced by 47% drank 5 cups can be reduced by 60%.The results also indicated that Ross and other daily coffee drinking, the more chance the next lower occurrence of Parkinson’s disease. ((To reduce the risk of dementia drink several cups of coffee good? The answer is on the next page))
Reduce the risk of senile dementia, day drinking three to five cups of coffee the best
coffee help enhance short-term memory, but epidemiological studies related to long-term memory associated Azihaimo’s disease (Alzheimer’s disease), and has a small current dispute.Comprehensive epidemiological studies have found evidence that the current is not the same, but some scholars believe that overall, more inclined coffee has a protective effect.Some studies support the coffee can reduce cognitive decline, dementia (dementia) or Ezihaimo’s disease. Middle age drinking three to five cups of coffee a day can reduce the risk of dementia in old age. Eskelinen median follow a group of middle-aged 21 years, who have reached the age of 65~79 years, of which 1409 people (originally 71%) completed a new survey found that a total of 61 patients were diagnosed as dementia, 48 man A Zihai Mo’s disease. In this group of middle-aged people, there are those who drink coffee, the risk of suffering from dementia and Ezihaimo’s disease is reduced, which reduces the lowest risk of up to 65%. Overall, drank three to five cups of coffee, dementia and Azihaimo’s disease can be reduced by 30% and 42%, respectively. An object of study for up to 3,494 people ─ Honolulu Asia Aging Study (Honolulu-Asia Aging Study), found that neither coffee or caffeine, and any form of cognitive deterioration no correlation; but another case-control study found that, compared with high blood levels were less likely to progress to cognitive impairment, its prevention Ezihaimo’s disease cognitive dysfunction in the central nervous system may be associated with common effects of caffeine, chlorogenic acid, or both related. Japan has conducted analysis of 23,091 people aged 65 bit older than or equal to, and found that coffee may reduce the risk of dementia. This article is taken “Coffee Addiction Research: find coffee healthy forces” / Zhang Jinjian, Caichong Huang (physician) / Raw waterFurther reading
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